Ontology highlight
ABSTRACT:
SUBMITTER: Kulig P
PROVIDER: S-EPMC5133729 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Kulig Paulina P Musiol Stephanie S Freiberger Sandra Nicole SN Schreiner Bettina B Gyülveszi Gabor G Russo Giancarlo G Pantelyushin Stanislav S Kishihara Kenji K Alessandrini Francesca F Kündig Thomas T Sallusto Federica F Hofbauer Günther F L GF Haak Stefan S Becher Burkhard B
Nature communications 20161128
Neutralization of the common p40-subunit of IL-12/23 in psoriasis patients has led to a breakthrough in the management of moderate to severe disease. Aside from neutralizing IL-23, which is thought to be responsible for the curative effect, anti-p40 therapy also interferes with IL-12 signalling and type 1 immunity. Here we dissect the individual contribution of these two cytokines to the formation of psoriatic lesions and understand the effect of therapeutic co-targeting of IL-12 and IL-23 in ps ...[more]