Ontology highlight
ABSTRACT:
SUBMITTER: Uribe-Herranz M
PROVIDER: S-EPMC3656131 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Uribe-Herranz Mireia M Lian Li-Hua LH Hooper Kirsten M KM Milora Katelynn A KA Jensen Liselotte E LE
The Journal of investigative dermatology 20130214 6
Munro's microabscesses contain polymorphonuclear leukocytes and form specifically in the epidermis of psoriasis patients. The mechanism whereby the neutrophils are recruited into the epidermis is poorly understood. Using a combination of human and mouse primary keratinocyte cell cultures and the imiquimod-induced psoriasis-like mouse model of skin inflammation, we explored the role of IL-1 signaling in microabscess formation. In vitro imiquimod stimulated production of IL-1α and neutrophil recru ...[more]