Ontology highlight
ABSTRACT:
SUBMITTER: Wang XB
PROVIDER: S-EPMC5134401 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Wang Xue-Bin XB Han Ya-di YD Zhang Shuai S Cui Ning-Hua NH Liu Ze-Jin ZJ Huang Zhu-Liang ZL Li Cong C Zheng Fang F
Journal of cellular and molecular medicine 20160729 12
Single nucleotide polymorphisms (SNPs) in thioredoxin-interacting protein (TXNIP) gene may modulate TXNIP expression, then increase the risk of coronary artery disease (CAD). In a two-stage case-control study with a total of 1818 CAD patients and 1963 controls, we genotyped three SNPs in TXNIP and found that the variant genotypes of SNPs rs7212 [odds ratio (OR) = 1.26, P = 0.001] and rs7211 (OR = 1.23, P = 0.005) were significantly associated with increased CAD risk under a dominant model. In ha ...[more]