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Flotillin-2 Gene Is Associated with Coronary Artery Disease in Chinese Han Population.

ABSTRACT: Flotillin-2, an important protein of vesicular endocytosis, is commonly used as a marker protein for lipid microdomains. It plays an essential role in cellular cholesterol uptake and biliary cholesterol reabsorption. Excessive cholesterol intake could cause dyslipidemia, which is a major risk factor of coronary artery disease (CAD).To investigate the association between the human flotillin-2 gene polymorphism and CAD in the Chinese Han population.Three single-nucleotide polymorphisms (SNPs; rs10205, rs3816848 and rs8081659) of the flotillin-2 gene were genotyped by real-time polymerase chain reaction in 307 CAD patients and 441 control subjects.The genotypic distribution of these three SNPs was significantly different between CAD patients and control subjects (all p?

SUBMITTER: Luo JY

PROVIDER: S-EPMC4677510 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Flotillin-2 Gene Is Associated with Coronary Artery Disease in Chinese Han Population.

Luo Jun-Yi JY Fu Zhen-Yan ZY Maimaiti Ailifeire A Zhou Yun Y Yang Yi-Ning YN Yu Zi-Xiang ZX Chen Bang-Dang BD Liu Fen F Ma Yi-Tong YT

Genetic testing and molecular biomarkers 20151110 12

<h4>Background</h4>Flotillin-2, an important protein of vesicular endocytosis, is commonly used as a marker protein for lipid microdomains. It plays an essential role in cellular cholesterol uptake and biliary cholesterol reabsorption. Excessive cholesterol intake could cause dyslipidemia, which is a major risk factor of coronary artery disease (CAD).<h4>Aims</h4>To investigate the association between the human flotillin-2 gene polymorphism and CAD in the Chinese Han population.<h4>Materials and ...[more]

PMID: 26556629

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