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Structural insights into functional amyloid inhibition in Gram -ve bacteria.

ABSTRACT: Amyloids are proteinaceous aggregates known for their role in debilitating degenerative diseases involving protein dysfunction. Many forms of functional amyloid are also produced in nature and often these systems require careful control of their assembly to avoid the potentially toxic effects. The best-characterised functional amyloid system is the bacterial curli system. Three natural inhibitors of bacterial curli amyloid have been identified and recently characterised structurally. Here, we compare common structural features of CsgC, CsgE and CsgH and discuss the potential implications for general inhibition of amyloid.

SUBMITTER: Hawthorne W

PROVIDER: S-EPMC5135000 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Structural insights into functional amyloid inhibition in Gram -ve bacteria.

Hawthorne William W Rouse Sarah S Sewell Lee L Matthews Stephen J SJ

Biochemical Society transactions 20161201 6

Amyloids are proteinaceous aggregates known for their role in debilitating degenerative diseases involving protein dysfunction. Many forms of functional amyloid are also produced in nature and often these systems require careful control of their assembly to avoid the potentially toxic effects. The best-characterised functional amyloid system is the bacterial curli system. Three natural inhibitors of bacterial curli amyloid have been identified and recently characterised structurally. Here, we co ...[more]

PMID: 27913673

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