Ontology highlight
ABSTRACT:
SUBMITTER: Skau CT
PROVIDER: S-EPMC5135586 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Skau Colleen T CT Fischer Robert S RS Gurel Pinar P Thiam Hawa Racine HR Tubbs Anthony A Baird Michelle A MA Davidson Michael W MW Piel Matthieu M Alushin Gregory M GM Nussenzweig Andre A Steeg Patricia S PS Waterman Clare M CM
Cell 20161110 6
Cell migration in confined 3D tissue microenvironments is critical for both normal physiological functions and dissemination of tumor cells. We discovered a cytoskeletal structure that prevents damage to the nucleus during migration in confined microenvironments. The formin-family actin filament nucleator FMN2 associates with and generates a perinuclear actin/focal adhesion (FA) system that is distinct from previously characterized actin/FA structures. This system controls nuclear shape and posi ...[more]