Ontology highlight
ABSTRACT:
SUBMITTER: Roberts AB
PROVIDER: S-EPMC8274349 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Roberts Anya B AB Zhang Jitao J Raj Singh Vijay V Nikolić Miloš M Moeendarbary Emad E Kamm Roger D RD So Peter T C PTC Scarcelli Giuliano G
Journal of biomechanics 20210405
During cancer metastasis, tumor cells undergo significant deformation in order to traverse through endothelial cell junctions in the walls of blood vessels. As cells pass through narrow gaps, smaller than the nuclear diameter, the spatial configuration of chromatin must change along with the distribution of nuclear enzymes. Nuclear stiffness is an important determinant of the ability of cells to undergo transendothelial migration, yet no studies have been conducted to assess whether tumor cell c ...[more]