A Radium-223 microgenerator from cyclotron-produced trace Actinium-227.
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ABSTRACT:
SUBMITTER: Abou DS
PROVIDER: S-EPMC5136344 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
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A Radium-223 microgenerator from cyclotron-produced trace Actinium-227.
Abou Diane S DS Pickett Juile J Mattson John E JE Thorek Daniel L J DLJ
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20161104
The alpha particle emitter Radium-223 dichloride (<sup>223</sup>RaCl<sub>2</sub>) has recently been approved for treatment of late-stage bone metastatic prostate cancer. There is considerable interest in studying this new agent outside of the clinical setting, however the supply of <sup>223</sup>Ra is limited and expensive. We have engineered a <sup>223</sup>Ra microgenerator using traces of <sup>227</sup>Ac previously generated from cyclotron-produced <sup>225</sup>Ac. Radiochemically pure <sup ...[more]
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