Ontology highlight
ABSTRACT:
SUBMITTER: Gebel J
PROVIDER: S-EPMC5136491 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Gebel Jakob J Luh Laura M LM Coutandin Daniel D Osterburg Christian C Löhr Frank F Schäfer Birgit B Frombach Ann-Sophie AS Sumyk Manuela M Buchner Lena L Krojer Tobias T Salah Eidarus E Mathea Sebastian S Güntert Peter P Knapp Stefan S Dötsch Volker V
Cell death and differentiation 20161007 12
Members of the p53 tumor-suppressor family are expressed as multiple isoforms. Isoforms with an N-terminal transactivation domain are transcriptionally active, while those ones lacking this domain often inhibit the transcriptional activity of other family members. In squamous cell carcinomas, the high expression level of ΔNp63α inhibits the tumor-suppressor function of TAp73β. This can in principle be due to blocking of the promoter or by direct interaction between both proteins. p63 and p73 can ...[more]