Ontology highlight
ABSTRACT:
SUBMITTER: Mimmler M
PROVIDER: S-EPMC5137439 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Mimmler Maximilian M Peter Simon S Kraus Alexander A Stroh Svenja S Nikolova Teodora T Seiwert Nina N Hasselwander Solveig S Neitzel Carina C Haub Jessica J Monien Bernhard H BH Nicken Petra P Steinberg Pablo P Shay Jerry W JW Kaina Bernd B Fahrer Jörg J
Nucleic acids research 20160905 21
PhIP is an abundant heterocyclic aromatic amine (HCA) and important dietary carcinogen. Following metabolic activation, PhIP causes bulky DNA lesions at the C8-position of guanine. Although C8-PhIP-dG adducts are mutagenic, their interference with the DNA replication machinery and the elicited DNA damage response (DDR) have not yet been studied. Here, we analyzed PhIP-triggered replicative stress and elucidated the role of the apical DDR kinases ATR, ATM and DNA-PK<sub>cs</sub> in the cellular d ...[more]