Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC5138852 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Wang Jian J Xu Wei W Zhong Tao T Song Zongbin Z Zou Yu Y Ding Zhuofeng Z Guo Qulian Q Dong Xinzhong X Zou Wangyuan W
Scientific reports 20161206
Morphine tolerance is a challenging clinical problem that limits its clinical application in pain treatment. Non-coding microRNAs (miRNAs) modulate gene expression in a post transcriptional manner, and their dysregulation causes various diseases. However, the significance of miRNAs in morphine tolerance is still poorly understood. In the present study, we hypothesized that microRNA-365 (miR-365) is a key functional small RNA that reverses morphine tolerance through regulation of β-arrestin 2 in ...[more]