Ontology highlight
ABSTRACT:
SUBMITTER: Turner HN
PROVIDER: S-EPMC5140760 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Turner Heather N HN Armengol Kevin K Patel Atit A AA Himmel Nathaniel J NJ Sullivan Luis L Iyer Srividya Chandramouli SC Bhattacharya Surajit S Iyer Eswar Prasad R EPR Landry Christian C Galko Michael J MJ Cox Daniel N DN
Current biology : CB 20161103 23
The basic mechanisms underlying noxious cold perception are not well understood. We developed Drosophila assays for noxious cold responses. Larvae respond to near-freezing temperatures via a mutually exclusive set of singular behaviors-in particular, a full-body contraction (CT). Class III (CIII) multidendritic sensory neurons are specifically activated by cold and optogenetic activation of these neurons elicits CT. Blocking synaptic transmission in CIII neurons inhibits CT. Genetically, the tra ...[more]