Organellar TRP channels.
Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC6785982 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Organellar TRP channels.
Zhang Xiaoli X Hu Meiqin M Yang Yexin Y Xu Haoxing H
Nature structural & molecular biology 20181029 11
Mammalian transient receptor potential (TRP) channels mediate Ca<sup>2+</sup> flux and voltage changes across membranes in response to environmental and cellular signals. At the plasma membrane, sensory TRPs act as neuronal detectors of physical and chemical environmental signals, and receptor-operated (metabotropic) TRPs decode extracellular neuroendocrine cues to control body homeostasis. In intracellular membranes, such as those in lysosomes, organellar TRPs respond to compartment-derived sig ...[more]
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