Ontology highlight
ABSTRACT:
SUBMITTER: Liu T
PROVIDER: S-EPMC5140778 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Oncogene 20160606 3
Smad proteins are central mediators in the canonical transforming growth factor-β (TGF-β) signaling pathway in mammalian cells. We report here that bromodomain-containing protein 7 (BRD7) functions as a novel transcription coactivator for Smads in TGF-β signaling. BRD7 forms a TGF-β inducible complex with Smad3/4 through its N-terminal Smad-binding domain. BRD7 simultaneously binds to acetylated histones to promote Smad-chromatin association, and associates with histone acetyltransferase p300 to ...[more]