Ontology highlight
ABSTRACT:
SUBMITTER: Marholz LJ
PROVIDER: S-EPMC5141568 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Marholz Laura J LJ Wang Wei W Zheng Yu Y Wang Xiang X
ACS medicinal chemistry letters 20151207 2
The discovery of the 5-methylcytosine (5mC) oxidation by the ten-eleven translocation (Tet) protein family was an important advancement in our understanding of DNA-modified epigenetics. Potent inhibitors of these proteins are greatly desired for both the understanding of the functions of these enzymes and to serve as eventual therapeutic leads. So far, the discovery of such small molecules with high affinity has been quite limited. Original tools to screen for activity are greatly needed in orde ...[more]