Ontology highlight
ABSTRACT:
SUBMITTER: Havenar-Daughton C
PROVIDER: S-EPMC5142765 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Cell reports 20161101 9
Generating tier 2 HIV-neutralizing antibody (nAb) responses by immunization remains a challenging problem, and the immunological barriers to induction of such responses with Env immunogens remain unclear. Here, some rhesus monkeys developed autologous tier 2 nAbs upon HIV Env trimer immunization (SOSIP.v5.2) whereas others did not. This was not because HIV Env trimers were immunologically silent because all monkeys made similar ELISA-binding antibody responses; the key difference was nAb versus ...[more]