Ontology highlight
ABSTRACT:
SUBMITTER: Zhao F
PROVIDER: S-EPMC7487785 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Zhao Fangzhu F Joyce Collin C Burns Alison A Nogal Bartek B Cottrell Christopher A CA Ramos Alejandra A Biddle Trevor T Pauthner Matthias M Nedellec Rebecca R Qureshi Huma H Mason Rosemarie R Landais Elise E Briney Bryan B Ward Andrew B AB Burton Dennis R DR Sok Devin D
Cell reports 20200901 10
BG505 SOSIP is a well-characterized near-native recombinant HIV Envelope (Env) trimer that holds promise as part of a sequential HIV immunogen regimen to induce broadly neutralizing antibodies (bnAbs). Rhesus macaques are considered the most appropriate pre-clinical animal model for monitoring antibody (Ab) responses. Accordingly, we report here the isolation of 45 BG505 autologous neutralizing antibodies (nAbs) with multiple specificities from SOSIP-immunized and BG505 SHIV-infected rhesus maca ...[more]