Ontology highlight
ABSTRACT:
SUBMITTER: Brosey CA
PROVIDER: S-EPMC5143173 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Brosey Chris A CA Ho Chris C Long Winnie Z WZ Singh Sukrit S Burnett Kathryn K Hura Greg L GL Nix Jay C JC Bowman Gregory R GR Ellenberger Tom T Tainer John A JA
Structure (London, England : 1993) 20161103 12
Apoptosis-inducing factor (AIF) is critical for mitochondrial respiratory complex biogenesis and for mediating necroptotic parthanatos; these functions are seemingly regulated by enigmatic allosteric switching driven by NADH charge-transfer complex (CTC) formation. Here, we define molecular pathways linking AIF's active site to allosteric switching regions by characterizing dimer-permissive mutants using small-angle X-ray scattering (SAXS) and crystallography and by probing AIF-CTC communication ...[more]