Ontology highlight
ABSTRACT:
SUBMITTER: Kadota I
PROVIDER: S-EPMC514422 | biostudies-literature | 2004 Aug
REPOSITORIES: biostudies-literature
Kadota Isao I Hu Yueqing Y Packard Garrick K GK Rychnovsky Scott D SD
Proceedings of the National Academy of Sciences of the United States of America 20040610 33
Polyene macrolide antibiotics are naturally occurring antifungal agents. Members of this class include amphotericin B, which has been used widely to treat systemic fungal infections. A general synthetic strategy has been devised to prepare polyol chains associated with the polyene macrolides. Cyanohydrin acetonide alkylations were used to assemble the carbon skeleton, and a simple modification of the strategy allowed an advanced intermediate to be converted to either the candidin polyol or the n ...[more]