Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy.
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ABSTRACT:
SUBMITTER: Liang Q
PROVIDER: S-EPMC5144538 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy.
Liang Qiming Q Luo Zhifei Z Zeng Jianxiong J Chen Weiqiang W Foo Suan-Sin SS Lee Shin-Ae SA Ge Jianning J Wang Su S Goldman Steven A SA Zlokovic Berislav V BV Zhao Zhen Z Jung Jae U JU
Cell stem cell 20160811 5
The current widespread outbreak of Zika virus (ZIKV) infection has been linked to severe clinical birth defects, particularly microcephaly, warranting urgent study of the molecular mechanisms underlying ZIKV pathogenesis. Akt-mTOR signaling is one of the key cellular pathways essential for brain development and autophagy regulation. Here, we show that ZIKV infection of human fetal neural stem cells (fNSCs) causes inhibition of the Akt-mTOR pathway, leading to defective neurogenesis and aberrant ...[more]
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