Ontology highlight
ABSTRACT:
SUBMITTER: Zhu P
PROVIDER: S-EPMC5146280 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Zhu Pingping P Wang Yanying Y Wu Jiayi J Huang Guanling G Liu Benyu B Ye Buqing B Du Ying Y Gao Guangxia G Tian Yong Y He Lei L Fan Zusen Z
Nature communications 20161201
Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence and heterogeneity of hepatocellular carcinoma (HCC). However, the biology of hepatic CSCs remains largely undefined. Through analysis of transcriptome microarray data, we identify a long noncoding RNA (lncRNA) called lncBRM, which is highly expressed in liver CSCs and HCC tumours. LncBRM is required for the self-renewal maintenance of liver CSCs and tumour initiation. In liver CSCs, lncBRM associates with BRM to initiat ...[more]