Dataset Information

Increased Age-Dependent Risk of Death Associated With lukF-PV-Positive Staphylococcus aureus Bacteremia.

ABSTRACT:

Background

Panton-Valentine leucocidin is a Staphylococcus aureus virulence factor encoded by lukF-PV and lukS-PV that is infrequent in S aureus bacteremia (SAB), and, therefore, little is known about risk factors and outcome of lukF-PV/lukS-PV-positive SAB.

Methods

This report is a register-based nationwide observational cohort study. lukF-PV was detected by polymerase chain reaction. Factors associated with the presence of lukF-PV were assessed by logistic regression analysis. Adjusted 30-day hazard ratios of mortality associated with lukF-PV status were computed by Cox proportional hazards regression analysis.

Results

Of 9490 SAB cases, 129 were lukF-PV-positive (1.4%), representing 14 different clonal complexes. lukF-PV was associated with younger age, absence of comorbidity, and methicillin-resistant S aureus. In unadjusted analysis, mortality associated with lukF-PV-positive SAB was comparable to SAB. However, lukF-PV-positive SAB nonsurvivors were significantly older and had more comorbidity. Consequently, by adjusted analysis, the risk of 30-day mortality was increased by 70% for lukF-PV-positive SAB compared with SAB (hazard ratio, 1.70; 95% confidence interval, 1.20-2.42; P = .003).

Conclusions

lukF-PV-positive SAB is rare in Denmark but associated with a significantly increased risk of mortality. Although the risk of lukF-PV-positive SAB was highest in the younger age groups, >80% of deaths associated with lukF-PV-positive SAB occurred in individuals older than 55 years.

SUBMITTER: Knudsen TA

PROVIDER: S-EPMC5146761 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Publications

Increased Age-Dependent Risk of Death Associated With <i>lukF-PV</i>-Positive <i>Staphylococcus aureus</i> Bacteremia.

Knudsen Trine A TA Skov Robert R Petersen Andreas A Larsen Anders R AR Benfield Thomas T

Open forum infectious diseases 20161001 4

<h4>Background</h4>Panton-Valentine leucocidin is a <i>Staphylococcus aureus</i> virulence factor encoded by <i>lukF-PV</i> and <i>lukS-PV</i> that is infrequent in <i>S aureus</i> bacteremia (SAB), and, therefore, little is known about risk factors and outcome of <i>lukF-PV</i>/<i>lukS-PV</i>-positive SAB.<h4>Methods</h4>This report is a register-based nationwide observational cohort study. <i>lukF-PV</i> was detected by polymerase chain reaction. Factors associated with the presence of <i>lukF ...[more]

PMID: 27957504

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