Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry.
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ABSTRACT:
SUBMITTER: Wen W
PROVIDER: S-EPMC5146840 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry.
Wen Wanqing W Shu Xiao-Ou XO Guo Xingyi X Cai Qiuyin Q Long Jirong J Bolla Manjeet K MK Michailidou Kyriaki K Dennis Joe J Wang Qin Q Gao Yu-Tang YT Zheng Ying Y Dunning Alison M AM García-Closas Montserrat M Brennan Paul P Chen Shou-Tung ST Choi Ji-Yeob JY Hartman Mikael M Ito Hidemi H Lophatananon Artitaya A Matsuo Keitaro K Miao Hui H Muir Kenneth K Sangrajrang Suleeporn S Shen Chen-Yang CY Teo Soo H SH Tseng Chiu-Chen CC Wu Anna H AH Yip Cheng Har CH Simard Jacques J Pharoah Paul D P PD Hall Per P Kang Daehee D Xiang Yongbing Y Easton Douglas F DF Zheng Wei W
Breast cancer research : BCR 20161208 1
<h4>Background</h4>Approximately 100 common breast cancer susceptibility alleles have been identified in genome-wide association studies (GWAS). The utility of these variants in breast cancer risk prediction models has not been evaluated adequately in women of Asian ancestry.<h4>Methods</h4>We evaluated 88 breast cancer risk variants that were identified previously by GWAS in 11,760 cases and 11,612 controls of Asian ancestry. SNPs confirmed to be associated with breast cancer risk in Asian wome ...[more]
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