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Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry.

ABSTRACT: BACKGROUND:Approximately 100 common breast cancer susceptibility alleles have been identified in genome-wide association studies (GWAS). The utility of these variants in breast cancer risk prediction models has not been evaluated adequately in women of Asian ancestry. METHODS:We evaluated 88 breast cancer risk variants that were identified previously by GWAS in 11,760 cases and 11,612 controls of Asian ancestry. SNPs confirmed to be associated with breast cancer risk in Asian women were used to construct a polygenic risk score (PRS). The relative and absolute risks of breast cancer by the PRS percentiles were estimated based on the PRS distribution, and were used to stratify women into different levels of breast cancer risk. RESULTS:We confirmed significant associations with breast cancer risk for SNPs in 44 of the 78 previously reported loci at P?

SUBMITTER: Wen W 

PROVIDER: S-EPMC5146840 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry.

Wen Wanqing W   Shu Xiao-Ou XO   Guo Xingyi X   Cai Qiuyin Q   Long Jirong J   Bolla Manjeet K MK   Michailidou Kyriaki K   Dennis Joe J   Wang Qin Q   Gao Yu-Tang YT   Zheng Ying Y   Dunning Alison M AM   García-Closas Montserrat M   Brennan Paul P   Chen Shou-Tung ST   Choi Ji-Yeob JY   Hartman Mikael M   Ito Hidemi H   Lophatananon Artitaya A   Matsuo Keitaro K   Miao Hui H   Muir Kenneth K   Sangrajrang Suleeporn S   Shen Chen-Yang CY   Teo Soo H SH   Tseng Chiu-Chen CC   Wu Anna H AH   Yip Cheng Har CH   Simard Jacques J   Pharoah Paul D P PD   Hall Per P   Kang Daehee D   Xiang Yongbing Y   Easton Douglas F DF   Zheng Wei W  

Breast cancer research : BCR 20161208 1

<h4>Background</h4>Approximately 100 common breast cancer susceptibility alleles have been identified in genome-wide association studies (GWAS). The utility of these variants in breast cancer risk prediction models has not been evaluated adequately in women of Asian ancestry.<h4>Methods</h4>We evaluated 88 breast cancer risk variants that were identified previously by GWAS in 11,760 cases and 11,612 controls of Asian ancestry. SNPs confirmed to be associated with breast cancer risk in Asian wome  ...[more]

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