An internationally spread clone of Streptococcus pneumoniae evolves from low-level to higher-level penicillin resistance by uptake of penicillin-binding protein gene fragments from nonencapsulated pneumococci.
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ABSTRACT:
SUBMITTER: Hauser C
PROVIDER: S-EPMC514746 | biostudies-literature | 2004 Sep
REPOSITORIES: biostudies-literature
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An internationally spread clone of Streptococcus pneumoniae evolves from low-level to higher-level penicillin resistance by uptake of penicillin-binding protein gene fragments from nonencapsulated pneumococci.
Hauser Christoph C Aebi Suzanne S Mühlemann Kathrin K
Antimicrobial agents and chemotherapy 20040901 9
Low-level penicillin resistance in an international Streptococcus pneumoniae serotype 19F clone emerging in Switzerland was characterized by mutations in the penicillin-binding protein PBP2x. Some isolates of this clone had evolved to higher resistance levels (penicillin MICs of 0.094 and 1 microg/ml), probably by acquisition of pbp2x fragments from local nonencapsulated pneumococci. ...[more]
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