Ontology highlight
ABSTRACT:
SUBMITTER: Dekens DW
PROVIDER: S-EPMC5147520 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Dekens Doortje W DW Naudé Petrus J W PJ Engelborghs Sebastiaan S Vermeiren Yannick Y Van Dam Debby D Oude Voshaar Richard C RC Eisel Ulrich L M UL De Deyn Peter P PP
Journal of Alzheimer's disease : JAD 20170101 2
Co-existing depression worsens Alzheimer's disease (AD) pathology. Neutrophil gelatinase-associated lipocalin (NGAL) is a newly identified (neuro)inflammatory mediator in the pathophysiologies of both AD and depression. This study aimed to compare NGAL levels in healthy controls, AD without depression (AD-D), and AD with co-existing depression (AD+D) patients. Protein levels of NGAL and its receptors, 24p3R and megalin, were assessed in nine brain regions from healthy controls (n = 19), AD-D (n ...[more]