Alpha Helices Are More Robust to Mutations than Beta Strands.
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ABSTRACT:
SUBMITTER: Abrusan G
PROVIDER: S-EPMC5147804 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Alpha Helices Are More Robust to Mutations than Beta Strands.
Abrusán György G Marsh Joseph A JA
PLoS computational biology 20161209 12
The rapidly increasing amount of data on human genetic variation has resulted in a growing demand to identify pathogenic mutations computationally, as their experimental validation is currently beyond reach. Here we show that alpha helices and beta strands differ significantly in their ability to tolerate mutations: helices can accumulate more mutations than strands without change, due to the higher numbers of inter-residue contacts in helices. This results in two patterns: a) the same number of ...[more]
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