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G Protein-Coupled Receptors Incorporated into Rehydrated Diblock Copolymer Vesicles Retain Functionality.

ABSTRACT: G protein-coupled receptor (GPCR) is incorporated into polymeric vesicles made up of diblock copolymer bilayers. Successfully incorporated GPCRs exhibit correct biased physiological orientation and respond to various ligands. After extended dehydrated storage via lyophilization and subsequent rehydration, diblock copolymer polymersomes retain their shape and incorporated GPCR retains its function.

SUBMITTER: Gutierrez MG

PROVIDER: S-EPMC5148614 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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G Protein-Coupled Receptors Incorporated into Rehydrated Diblock Copolymer Vesicles Retain Functionality.

Gutierrez M Gertrude MG Jalali-Yazdi Farzad F Peruzzi Justin J Riche Carson T CT Roberts Richard W RW Malmstadt Noah N

Small (Weinheim an der Bergstrasse, Germany) 20160816 38

G protein-coupled receptor (GPCR) is incorporated into polymeric vesicles made up of diblock copolymer bilayers. Successfully incorporated GPCRs exhibit correct biased physiological orientation and respond to various ligands. After extended dehydrated storage via lyophilization and subsequent rehydration, diblock copolymer polymersomes retain their shape and incorporated GPCR retains its function. ...[more]

PMID: 27529518

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