Ontology highlight
ABSTRACT:
SUBMITTER: Caslavka Zempel KE
PROVIDER: S-EPMC5148652 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Caslavka Zempel Katelyn E KE Vashisht Ajay A AA Barshop William D WD Wohlschlegel James A JA Clarke Steven G SG
Journal of proteome research 20161018 12
Methylation is a common and abundant post-translational modification. High-throughput proteomic investigations have reported many methylation sites from complex mixtures of proteins. The lack of consistency between parallel studies, resulting from both false positives and missed identifications, suggests problems with both over-reporting and under-reporting methylation sites. However, isotope labeling can be used effectively to address the issue of false-positives, and fractionation of proteins ...[more]