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Integrin ?7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma.


ABSTRACT: Non-CG methylation has been associated with stemness regulation in embryonic stem cells. By comparing differentially expressed genes affected by non-CG methylation between tumour and corresponding non-tumour tissues in oesophageal squamous cell carcinoma (OSCC), we find that Integrin ?7 (ITGA7) is characterized as a potential cancer stem cell (CSC) marker. Clinical data show that a high frequency of ITGA7+ cells in OSCC tissues is significantly associated with poor differentiation, lymph node metastasis and worse prognosis. Functional studies demonstrate that both sorted ITGA7+ cells and ITGA7 overexpressing cells display enhanced stemness features, including elevated expression of stemness-associated genes and epithelial-mesenchymal transition features, as well as increased abilities to self-renew, differentiate and resist chemotherapy. Mechanistic studies find that ITGA7 regulates CSC properties through the activation of the FAK-mediated signalling pathways. As knockdown of ITGA7 can effectively reduce the stemness of OSCC cells, ITGA7 could be a potential therapeutic target in OSCC treatment.

SUBMITTER: Ming XY 

PROVIDER: S-EPMC5150658 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma.

Ming Xiao-Yan XY   Fu Li L   Zhang Li-Yi LY   Qin Yan-Ru YR   Cao Ting-Ting TT   Chan Kwok Wah KW   Ma Stephanie S   Xie Dan D   Guan Xin-Yuan XY   Guan Xin-Yuan XY  

Nature communications 20161207


Non-CG methylation has been associated with stemness regulation in embryonic stem cells. By comparing differentially expressed genes affected by non-CG methylation between tumour and corresponding non-tumour tissues in oesophageal squamous cell carcinoma (OSCC), we find that Integrin α7 (ITGA7) is characterized as a potential cancer stem cell (CSC) marker. Clinical data show that a high frequency of ITGA7<sup>+</sup> cells in OSCC tissues is significantly associated with poor differentiation, ly  ...[more]

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