Ontology highlight
ABSTRACT:
SUBMITTER: Ming XY
PROVIDER: S-EPMC5150658 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Ming Xiao-Yan XY Fu Li L Zhang Li-Yi LY Qin Yan-Ru YR Cao Ting-Ting TT Chan Kwok Wah KW Ma Stephanie S Xie Dan D Guan Xin-Yuan XY Guan Xin-Yuan XY
Nature communications 20161207
Non-CG methylation has been associated with stemness regulation in embryonic stem cells. By comparing differentially expressed genes affected by non-CG methylation between tumour and corresponding non-tumour tissues in oesophageal squamous cell carcinoma (OSCC), we find that Integrin α7 (ITGA7) is characterized as a potential cancer stem cell (CSC) marker. Clinical data show that a high frequency of ITGA7<sup>+</sup> cells in OSCC tissues is significantly associated with poor differentiation, ly ...[more]