Dataset Information
Association between alcohol consumption and oesophageal microbiota in oesophageal squamous cell carcinoma.
Ontology highlight
ABSTRACT: Background
Microbiota has been reported to play a role in cancer patients. Nevertheless, little is known about the association between alcohol consumption and resultant changes in the diversity and composition of oesophageal microbiota in oesophageal squamous cell carcinoma (ESCC).Methods
We performed a hospital-based retrospective study of 120 patients with pathologically diagnosed primary ESCC. The relevant information for all study participants were collected through a detailed questionnaire. The differences in adjacent tissues between non-drinkers and drinkers were explored using 16S rRNA gene sequencing. Raw sequencing data were imported into QIIME 2 to analyse the diversity and abundance of microbiota. Linear discriminant analysis effect size (LEfSe) and unconditional logistic regression were performed to determine the bacterial taxa that were associated with drinking.Results
The Shannon diversity index and Bray-Curtis distance of oesophageal microbiota were significantly different among drinkers(P?ConclusionAlcohol consumption is associated with alterations in both the diversity and composition the of the oesophageal microbiota in ESCC patients.
SUBMITTER: Rao W
PROVIDER: S-EPMC7936487 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Association between alcohol consumption and oesophageal microbiota in oesophageal squamous cell carcinoma.
BMC microbiology 20210306 1
<h4>Background</h4>Microbiota has been reported to play a role in cancer patients. Nevertheless, little is known about the association between alcohol consumption and resultant changes in the diversity and composition of oesophageal microbiota in oesophageal squamous cell carcinoma (ESCC).<h4>Methods</h4>We performed a hospital-based retrospective study of 120 patients with pathologically diagnosed primary ESCC. The relevant information for all study participants were collected through a detaile ...[more]