Ontology highlight
ABSTRACT:
SUBMITTER: Wu Z
PROVIDER: S-EPMC5150680 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Wu Zhaoyang Z Lu Yu Y Li Linhu L Zhao Rui R Wang Bin B Lv Kai K Liu Mingliang M You Xuefu X
ACS medicinal chemistry letters 20161011 12
A series of imidazo[1,2-<i>a</i>]pyridine carboxamides (IPAs) bearing an <i>N</i>-(2-phenoxyethyl) moiety was designed and synthesized as new antitubercular agents. Seven 2,6-dimethyl IPAs demonstrated excellent <i>in vitro</i> activity (MIC: 0.025-0.054 μg/mL) against the drug susceptive H37Rv strain and two clinically isolated multidrug-resistant <i>Mycobacterium tuberculosis</i>strains. Compound <b>10j</b> displayed acceptable safety and pharmacokinetic properties, opening a new direction for ...[more]