Ontology highlight
ABSTRACT:
SUBMITTER: Moraski GC
PROVIDER: S-EPMC4958206 | biostudies-other | 2016 Aug
REPOSITORIES: biostudies-other
Moraski Garrett C GC Cheng Yong Y Cho Sanghyun S Cramer Jeffrey W JW Godfrey Alexander A Masquelin Thierry T Franzblau Scott G SG Miller Marvin J MJ Schorey Jeffery J
Antimicrobial agents and chemotherapy 20160722 8
A panel of six imidazo[1,2-a]pyridine-3-carboxamides (IAPs) were shown to have low-micromolar activity against Mycobacterium avium strains. Compound ND-10885 (compound 2) showed significant activity in the lung, spleen, and liver in a mouse M. avium infection model. A combined regimen consisting of ND-10885 (compound 2) and rifampin was additive in its anti-M. avium activity in the lung. Our data indicate that IAPs represent a new class of antibiotics that are active against M. avium and could p ...[more]