Ontology highlight
ABSTRACT:
SUBMITTER: Lassi G
PROVIDER: S-EPMC5152594 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Lassi Glenda G Taylor Amy E AE Timpson Nicholas J NJ Kenny Paul J PJ Mather Robert J RJ Eisen Tim T Munafò Marcus R MR
Trends in neurosciences 20161118 12
Genome-wide association studies (GWASs) have identified associations between the CHRNA5-CHRNA3-CHRNB4 gene cluster and smoking heaviness and nicotine dependence. Studies in rodents have described the anatomical localisation and function of the nicotinic acetylcholine receptors (nAChRs) formed by the subunits encoded by this gene cluster. Further investigations that complemented these studies highlighted the variability of individuals' smoking behaviours and their ability to adjust nicotine intak ...[more]