Ontology highlight
ABSTRACT:
SUBMITTER: Zhu AZ
PROVIDER: S-EPMC4111775 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Zhu A Z X AZ Zhou Q Q Cox L S LS David S P SP Ahluwalia J S JS Benowitz N L NL Tyndale R F RF
Clinical pharmacology and therapeutics 20140414 2
Associations between CHRNA5-A3-B4 variants and smoking behaviors exist; however, the association with smoking abstinence is less understood, particularly that among African Americans. In 1,295 African Americans enrolled in two clinical trials, we investigated the association between CHRNA5-A3-B4 and smoking abstinence. The rs2056527(A) allele was associated with lower abstinence with active pharmacotherapy (during treatment: odds ratio (OR) = 0.42, P < 0.001; end of treatment (EOT): OR = 0.55, P ...[more]