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Polybrominated diphenyl ether exposure and reproductive hormones in North American men.

ABSTRACT: Polybrominated diphenyl ethers (PBDEs) are flame retardant chemicals that are persistent organic pollutants. Animal experiments and some human studies indicate that PBDEs may adversely affect male reproductive function.To assess the association between PBDE exposure and reproductive hormones (RHs) in a North American male adult cohort.From 2010-11, we collected three serum samples from 27 healthy adult men. We assessed associations between PBDEs and RHs using mixed effect regression models.PBDEs were inversely associated with inhibin-B. In older men, increased concentrations of BDE-47 and BDE-100 were significantly associated with a decrease in inhibin-B, and an increase in follicular stimulating hormone (FSH).These findings suggest PBDE exposure may affect RHs in older men. We did not measure other parameters of male reproductive function and therefore these results are preliminary.

SUBMITTER: Makey CM

PROVIDER: S-EPMC5152616 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Polybrominated diphenyl ether exposure and reproductive hormones in North American men.

Makey Colleen M CM McClean Michael D MD Braverman Lewis E LE Pearce Elizabeth N EN Sjödin Andreas A Weinberg Janice J Webster Thomas F TF

Reproductive toxicology (Elmsford, N.Y.) 20160414

<h4>Background</h4>Polybrominated diphenyl ethers (PBDEs) are flame retardant chemicals that are persistent organic pollutants. Animal experiments and some human studies indicate that PBDEs may adversely affect male reproductive function.<h4>Objectives</h4>To assess the association between PBDE exposure and reproductive hormones (RHs) in a North American male adult cohort.<h4>Methods</h4>From 2010-11, we collected three serum samples from 27 healthy adult men. We assessed associations between PB ...[more]

PMID: 27094376

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Project description:BackgroundPolybrominated diphenyl ethers (PBDEs) are flame-retardant chemicals that are added to many consumer products. Multiple animal studies have shown PBDEs to be thyroid hormone (TH) disruptors. Epidemiologic evidence of PBDE exposure associated with TH disruption has been inconclusive.ObjectivesWe used repeated measures to estimate associations between serum PBDE concentrations and THs in a North American adult cohort.MethodsFrom 2010 to 2011, we collected ≤ 3 serum samples at approximately 6-month intervals from 52 healthy adult office workers from Boston, Massachusetts, for analysis of PBDE congeners and THs.ResultsThe geometric mean sum concentrations of the most prevalent PBDE congeners (BDE-28, BDE-47, BDE-99, BDE-100, and BDE-153) were 22 ng/g lipid in winter 2010, 23 ng/g lipid in summer 2010, and 19 ng/g lipid in winter 2011. BDE-47 was the predominant congener. Based on a multivariable mixed regression model, we estimated that on average, a 1-ng/g serum increase in BDE-47 was associated with a 2.6-μg/dL decrease in total thyroxine (T4) (95% CI: -4.7, -0.35). Total T4 was inversely associated with each PBDE congener. Serum concentrations of PBDEs were not strongly associated with total triiodothyronine (T3), free T4, or thyroid-stimulating hormone (TSH).ConclusionThese results are consistent with those from animal studies showing that exposure to PBDEs is associated with a decrease in serum T4. Because the other TH concentrations did not appear to be associated with BDE exposures, our findings do not indicate effects on the pituitary-thyroid axis. Taken together, our findings suggest that PBDE exposure might decrease the binding of T4 to serum T4 binding proteins.CitationMakey CM, McClean MD, Braverman LE, Pearce EN, He XM, Sjödin A, Weinberg JM, Webster TF. 2016. Polybrominated diphenyl ether exposure and thyroid function tests in North American adults. Environ Health Perspect 124:420-425; http://dx.doi.org/10.1289/ehp.1509755.

Dataset Information

Polybrominated diphenyl ether exposure and reproductive hormones in North American men.

Publications

Polybrominated diphenyl ether exposure and reproductive hormones in North American men.

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