Ontology highlight
ABSTRACT:
SUBMITTER: Khavandi K
PROVIDER: S-EPMC5154376 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Khavandi Kaivan K Baylie Rachael A RA Sugden Sarah A SA Ahmed Majid M Csato Viktoria V Eaton Philip P Hill-Eubanks David C DC Bonev Adrian D AD Nelson Mark T MT Greenstein Adam S AS
Science signaling 20161011 449
Activation of Ca<sup>2+</sup>-sensitive, large-conductance potassium (BK) channels in vascular smooth muscle cells (VSMCs) by local, ryanodine receptor-mediated Ca<sup>2+</sup> signals (Ca<sup>2+</sup> sparks) acts as a brake on pressure-induced (myogenic) vasoconstriction-a fundamental mechanism that regulates blood flow in small resistance arteries. We report that physiological intraluminal pressure within resistance arteries activated cGMP-dependent protein kinase (PKG) in VSMCs through oxida ...[more]