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Porphyrin conjugated SiC/SiOx nanowires for X-ray-excited photodynamic therapy.

ABSTRACT: The development of innovative nanosystems opens new perspectives for multidisciplinary applications at the frontier between materials science and nanomedicine. Here we present a novel hybrid nanosystem based on cytocompatible inorganic SiC/SiOx core/shell nanowires conjugated via click-chemistry procedures with an organic photosensitizer, a tetracarboxyphenyl porphyrin derivative. We show that this nanosystem is an efficient source of singlet oxygen for cell oxidative stress when irradiated with 6?MV X-Rays at low doses (0.4-2?Gy). The in-vitro clonogenic survival assay on lung adenocarcinoma cells shows that 12 days after irradiation at a dose of 2?Gy, the cell population is reduced by about 75% with respect to control cells. These results demonstrate that our approach is very efficient to enhance radiation therapy effects for cancer treatments.

SUBMITTER: Rossi F

PROVIDER: S-EPMC5154586 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Porphyrin conjugated SiC/SiOx nanowires for X-ray-excited photodynamic therapy.

Rossi F F Bedogni E E Bigi F F Rimoldi T T Cristofolini L L Pinelli S S Alinovi R R Negri M M Dhanabalan S C SC Attolini G G Fabbri F F Goldoni M M Mutti A A Benecchi G G Ghetti C C Iannotta S S Salviati G G

Scientific reports 20150105

The development of innovative nanosystems opens new perspectives for multidisciplinary applications at the frontier between materials science and nanomedicine. Here we present a novel hybrid nanosystem based on cytocompatible inorganic SiC/SiOx core/shell nanowires conjugated via click-chemistry procedures with an organic photosensitizer, a tetracarboxyphenyl porphyrin derivative. We show that this nanosystem is an efficient source of singlet oxygen for cell oxidative stress when irradiated with ...[more]

PMID: 25556299

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