Ontology highlight
ABSTRACT:
SUBMITTER: Hannah-Shmouni F
PROVIDER: S-EPMC5154831 | biostudies-literature | 2016 Oct - Dec
REPOSITORIES: biostudies-literature
Hannah-Shmouni Fady F Trivellin Giampaolo G Stratakis Constantine A CA
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 20160810
Gigantism and acromegaly are rare disorders that are caused by excessive GH secretion and/or high levels of its mediator, IGF-1. Gigantism occurs when excess GH or IGF-1 lead to increased linear growth, before the end of puberty and epiphyseal closure. The majority of cases arise from a benign GH-secreting pituitary adenoma, with an incidence of pituitary gigantism and acromegaly of approximately 8 and 11 per million person-years, respectively. Over the past two decades, our increasing understan ...[more]