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Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study.

ABSTRACT: A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted.

SUBMITTER: Wang L 

PROVIDER: S-EPMC5154911 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study.

Wang Lisa L   Heckman Michael G MG   Aasly Jan O JO   Annesi Grazia G   Bozi Maria M   Chung Sun Ju SJ   Clarke Carl C   Crosiers David D   Eckstein Gertrud G   Garraux Gaetan G   Hadjigeorgiou Georgios M GM   Hattori Nobu N   Jeon Beom B   Kim Yun J YJ   Kubo Masato M   Lesage Suzanne S   Lin Juei Jueng JJ   Lynch Timothy T   Lichtner Peter P   Mellick George D GD   Mok Vincent V   Morrison Karin E KE   Quattrone Aldo A   Satake Wataru W   Silburn Peter A PA   Stefanis Leonidas L   Stockton Joanne D JD   Tan Eng King EK   Toda Tatsushi T   Brice Alexis A   Van Broeckhoven Christine C   Uitti Ryan J RJ   Wirdefeldt Karin K   Wszolek Zbigniew Z   Xiromerisiou Georgia G   Maraganore Demetrius M DM   Gasser Thomas T   Krüger Rejko R   Farrer Matthew J MJ   Ross Owen A OA   Sharma Manu M  

Neurobiology of aging 20161006

A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and  ...[more]

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