Ontology highlight
ABSTRACT:
SUBMITTER: Pawlowski AC
PROVIDER: S-EPMC5155152 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Pawlowski Andrew C AC Wang Wenliang W Koteva Kalinka K Barton Hazel A HA McArthur Andrew G AG Wright Gerard D GD
Nature communications 20161208
Antibiotic resistance is ancient and widespread in environmental bacteria. These are therefore reservoirs of resistance elements and reflective of the natural history of antibiotics and resistance. In a previous study, we discovered that multi-drug resistance is common in bacteria isolated from Lechuguilla Cave, an underground ecosystem that has been isolated from the surface for over 4 Myr. Here we use whole-genome sequencing, functional genomics and biochemical assays to reveal the intrinsic r ...[more]