Ontology highlight
ABSTRACT:
SUBMITTER: Ge X
PROVIDER: S-EPMC5155318 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Ge Xianglian X Xi Haitao H Yang Fayu F Zhi Xiao X Fu Yanghua Y Chen Ding D Xu Ren-He RH Lin Ge G Qu Jia J Zhao Junzhao J Gu Feng F Gu Feng F
Molecular therapy. Nucleic acids 20161129 11
Clustered interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9)-mediated genome engineering technologies are sparking a new revolution in biological research. This technology efficiently induces DNA double strand breaks at the targeted genomic sequence and results in indel mutations by the error-prone process of nonhomologous end joining DNA repair or homologous recombination with a DNA repair template. The efficiency of genome editing with CRISPR/Cas9 alone in human ...[more]