Ontology highlight
ABSTRACT:
SUBMITTER: Dhalluin C
PROVIDER: S-EPMC5155437 | biostudies-literature | 2000 Oct
REPOSITORIES: biostudies-literature
Dhalluin C C Yan K S KS Plotnikova O O Lee K W KW Zeng L L Kuti M M Mujtaba S S Goldfarb M P MP Zhou M M MM
Molecular cell 20001001 4
SNT adaptor proteins transduce activation of fibroblast growth factor receptors (FGFRs) and neurotrophin receptors (TRKs) to common signaling targets. The SNT-1 phosphotyrosine binding (PTB) domain recognizes activated TRKs at a canonical NPXpY motif and, atypically, binds to nonphosphorylated FGFRs in a region lacking tyrosine or asparagine. Here, using NMR and mutational analyses, we show that the PTB domain utilizes distinct sets of amino acid residues to interact with FGFRs or TRKs in a mutu ...[more]