Ontology highlight
ABSTRACT:
SUBMITTER: Sripathi SR
PROVIDER: S-EPMC5155442 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Sripathi Srinivas R SR Sylvester O'Donnell O He Weilue W Moser Trevor T Um Ji-Yeon JY Lamoke Folami F Ramakrishna Wusirika W Bernstein Paul S PS Bartoli Manuela M Jahng Wan Jin WJ
The protein journal 20160201 1
Previously, our molecular binding study showed that prohibitin interacts with phospholipids, including phosphatidylinositide and cardiolipin. Under stress conditions, prohibitin interacts with cardiolipin as a retrograde response to activate mitochondrial proliferation. The lipid-binding switch mechanism of prohibitin with phosphatidylinositol-3,4,5-triphosphate and cardiolipin may suggest the role of prohibitin effects on energy metabolism and age-related diseases. The current study examined th ...[more]