Ontology highlight
ABSTRACT:
SUBMITTER: Go YM
PROVIDER: S-EPMC7811279 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Go Young-Mi YM Zhang Jing J Fernandes Jolyn J Litwin Christopher C Chen Rui R Wensel Theodore G TG Jones Dean P DP Cai Jiyang J Chen Yan Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20200728 9
The retinal pigment epithelium (RPE) is a particularly vulnerable tissue to age-dependent degeneration. Over the life span, the RPE develops an expanded endo-lysosomal compartment to maintain the high efficiency of phagocytosis and degradation of photoreceptor outer segments (POS) necessary for photoreceptor survival. As the assembly and activation of the mechanistic target of rapamycin complex 1 (mTORC1) occur on the lysosome surface, increased lysosome mass with aging leads to higher mTORC1 ac ...[more]