DNA Antenna Tile-Associated Deoxyribozyme Sensor with Improved Sensitivity.
Ontology highlight
ABSTRACT:
SUBMITTER: Cox AJ
PROVIDER: S-EPMC5156317 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
DNA Antenna Tile-Associated Deoxyribozyme Sensor with Improved Sensitivity.
Cox Amanda J AJ Bengtson Hillary N HN Gerasimova Yulia V YV Rohde Kyle H KH Kolpashchikov Dmitry M DM
Chembiochem : a European journal of chemical biology 20160913 21
Some natural enzymes increase the rate of diffusion-limited reactions by facilitating substrate flow to their active sites. Inspired by this natural phenomenon, we developed a strategy for efficient substrate delivery to a deoxyribozyme (DZ) catalytic sensor. This resulted in a three- to fourfold increase in sensitivity and up to a ninefold improvement in the detection limit. The reported strategy can be used to enhance catalytic efficiency of diffusion-limited enzymes and to improve sensitivity ...[more]
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