Association of Cell Adhesion Molecules Contactin-6 and Latrophilin-1 Regulates Neuronal Apoptosis.
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ABSTRACT:
SUBMITTER: Zuko A
PROVIDER: S-EPMC5156884 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
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Association of Cell Adhesion Molecules Contactin-6 and Latrophilin-1 Regulates Neuronal Apoptosis.
Zuko Amila A Oguro-Ando Asami A Post Harm H Taggenbrock Renske L R E RL van Dijk Roland E RE Altelaar A F Maarten AF Heck Albert J R AJ Petrenko Alexander G AG van der Zwaag Bert B Shimoda Yasushi Y Pasterkamp R J RJ Burbach J P H JP
Frontiers in molecular neuroscience 20161215
In view of important neurobiological functions of the cell adhesion molecule contactin-6 (Cntn6) that have emerged from studies on null-mutant mice and autism spectrum disorders patients, we set out to examine pathways underlying functions of Cntn6 using a proteomics approach. We identified the cell adhesion GPCR latrophilin-1 (Lphn1, a.k.a. CIRL1/CL, ADGRL1) as a binding partner for Cntn6 forming together a heteromeric <i>cis</i>-complex. Lphn1 expression in cultured neurons caused reduction in ...[more]
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