Ontology highlight
ABSTRACT:
SUBMITTER: Lu YC
PROVIDER: S-EPMC4851429 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20150730 9
Fibronectin leucine-rich repeat transmembrane proteins (FLRTs) are cell-adhesion molecules with emerging functions in cortical development and synapse formation. Their extracellular regions interact with latrophilins (LPHNs) to mediate synapse development, and with Uncoordinated-5 (UNC5)/netrin receptors to control the migration of neurons in the developing cortex. Here, we present the crystal structures of FLRT3 in isolation and in complex with LPHN3. The LPHN3/FLRT3 structure reveals that LPHN ...[more]