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Thumb Imprint Based Detection of Hyperbilirubinemia Using Luminescent Gold Nanoclusters.

ABSTRACT: Early and easy detection of diseases, using point-of-care and inexpensive devices, not only provides option for early treatment but also reduces the risk of propagation. Herein we report the fabrication of a robust film based luminescence indicator of bilirubin, which can indicate hyperbilirubinemia through the thumb imprint of the patient. The UV-light induced luminescence intensity of the film, made out of chitosan stabilised gold (Au) nanoclusters, which was effectively quenched in the presence of Cu²⁺ ions, recovered in the presence of bilirubin from skin or blood serum. Moreover, the sensitivity of detection of bilirubin was tuneable with the amount of Cu²⁺ added, thereby facilitating the detection of the desired concentration range of bilirubin.

SUBMITTER: Basu S

PROVIDER: S-EPMC5157017 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Thumb Imprint Based Detection of Hyperbilirubinemia Using Luminescent Gold Nanoclusters.

Basu Srestha S Sahoo Amaresh Kumar AK Paul Anumita A Chattopadhyay Arun A

Scientific reports 20161215

Early and easy detection of diseases, using point-of-care and inexpensive devices, not only provides option for early treatment but also reduces the risk of propagation. Herein we report the fabrication of a robust film based luminescence indicator of bilirubin, which can indicate hyperbilirubinemia through the thumb imprint of the patient. The UV-light induced luminescence intensity of the film, made out of chitosan stabilised gold (Au) nanoclusters, which was effectively quenched in the presen ...[more]

PMID: 27976728

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