Browse
Submit Data
Databases
API
Help

Dataset Information

19 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Tandem copper and gold nanoclusters for two-color ratiometric explosives detection.

ABSTRACT: We report a sensory platform for the determination of common explosive species (e.g., TNT, PETN, RDX) based on the differential response from two different luminescent metal nanoclusters. In particular, whereas the red emission from bovine serum albumin-protected gold nanoclusters was strongly quenched by nitro-, nitrate-, and nitroamine-containing explosive organic molecules, blue-emitting glutathione-capped copper nanoclusters proved inert to quenching by these same analytes, instead showing evidence for aggregation-induced emission enhancement (AIEE). As a result, this discrete gold/copper nanocluster pairing provides a dual-probe, ratiometric (red-to-blue) system signaling the presence of TNT and other common explosives. This strategy opens up new potential for nanocluster-based analyte signaling, with implications to fluorescence resonance energy transfer (FRET) strategies as well.

SUBMITTER: Essner JB

PROVIDER: S-EPMC5831381 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Tandem copper and gold nanoclusters for two-color ratiometric explosives detection.

Essner Jeremy B JB Chen Xi X Wood Troy D TD Baker Gary A GA

The Analyst 20180201 5

We report a sensory platform for the determination of common explosive species (e.g., TNT, PETN, RDX) based on the differential response from two different luminescent metal nanoclusters. In particular, whereas the red emission from bovine serum albumin-protected gold nanoclusters was strongly quenched by nitro-, nitrate-, and nitroamine-containing explosive organic molecules, blue-emitting glutathione-capped copper nanoclusters proved inert to quenching by these same analytes, instead showing e ...[more]

PMID: 29423479

Similar Datasets

Copper (II) Ion-Modified Gold Nanoclusters as Peroxidase Mimetics for the Colorimetric Detection of Pyrophosphate.

Project description:Copper (II) ions have been shown to greatly improve the chemical stability and peroxidase-like activity of gold nanoclusters (AuNCs). Since the affinity between Cu2+ and pyrophosphate (PPi) is higher than that between Cu2+ and AuNCs, the catalytic activity of AuNCs-Cu2+ decreases with the introduction of PPi. Based on this principle, a new colorimetric detection method of PPi with high sensitivity and selectivity was developed by using AuNCs-Cu2+ as a probe. Under optimized conditions, the detection limit of PPi was 0.49 nM with a linear range of 0.51 to 30,000 nM. The sensitivity of the method was three orders of magnitude higher than that of a fluorescence method using AuNCs-Cu2+ as the probe. Finally, the AuNCs-Cu2+ system was successfully applied to directly determine the concentration of PPi in human urine samples.

| S-EPMC8400922 | biostudies-literature

Fabrication of cefotaxime sodium-functionalized gold nanoclusters for the detection of copper ions in Chinese herbal medicines.

Project description:Antibiotic-based gold nanoclusters (AuNCs) are a good sensing platform for specific recognition; however, the related studies are few. Herein, a simple and facile strategy was proposed for the fabrication of bright blue fluorescent AuNCs through the degradation product (DCTX) of cefotaxime sodium that induced the reduction of HAuCl4. Various analytical techniques were applied to characterize the prepared AuNCs@DCTX. AuNCs@DCTX exhibited a strong emission peak centered at 420 nm and a quantum yield of 11.8%. Furthermore, an aggregation-induced fluorescence quenching mode endowed the AuNCs@DCTX probe with good specificity and sensitivity for Cu2+ detection. The proposed probe had a linear range of 0.01-40 μM, a precision with a relative standard deviation of 1.2% (n = 8), and a detection limit of 8 nM (signal/noise = 3). Interestingly, the probe could be reused through switching the "off" and "on" states by the addition of Cu2+ and EDTA. The practicality of the sensing platform was investigated for the determination of Cu2+ in four Chinese herbal medicines (CHMs), and the results were in accordance with those obtained by the FAAS method. This study has provided an alternate way for the fabrication of thiolate-protected AuNCs for sensing applications.

| S-EPMC9060655 | biostudies-literature

Rational Design of "Three-in-One" Ratiometric Nanoprobes: Protein-Caged Dityrosine, CdS Quantum Dots, and Gold Nanoclusters.

Project description:Recently, multiplexed ratiometric fluorescence sensors for detecting several analytes have received much interest because of their multifunctionality. Here, we fabricate a novel trinity fluorescent nanoprobe in which one small-molecule fluorophore, blue-emissive dityrosine (diTyr) residues, and two nanomaterial fluorophores, green-emissive CdS quantum dots (CdSQDs) and red-emissive gold nanoclusters (AuNCs), are cocaged in a bovine serum albumin (BSA) molecule. The large differences of Stokes shifts among diTyr residues, CdSQDs, and AuNCs ensure their emission at a single excitation wavelength. The nanoprobes can be facilely integrated using two-step synthetic reactions. DiTyr residues and AuNCs are formed and bound to the protein cage through the redox reaction between Au3+ and tyrosine residues of BSA, and the CdSQDs are followed to be conjugated to the modified BSA cage-templated CdS combination reaction. With established benign biocompatibility, the nanoprobes can ratiometrically detect intracellular glutathione by significantly enhancing the green emission of the conjugated CdSQDs. Likewise, the ratiometric sensing of solution alkalinity and tris(2-carboxyethyl)phosphine can be achieved using blue-emitted diTyr residues and red-emitted AuNCs as the responsive units, respectively, and the corresponding other two fluorophores as the reference signals. This study addresses a concept of trinity fluorescence ratiometric sensing system with multiple targets and optional references, which should be a promising pathway to meet the challenges from complexing biochemical environments and multivariate analysis.

| S-EPMC7178766 | biostudies-literature

Thumb Imprint Based Detection of Hyperbilirubinemia Using Luminescent Gold Nanoclusters.

Project description:Early and easy detection of diseases, using point-of-care and inexpensive devices, not only provides option for early treatment but also reduces the risk of propagation. Herein we report the fabrication of a robust film based luminescence indicator of bilirubin, which can indicate hyperbilirubinemia through the thumb imprint of the patient. The UV-light induced luminescence intensity of the film, made out of chitosan stabilised gold (Au) nanoclusters, which was effectively quenched in the presence of Cu2+ ions, recovered in the presence of bilirubin from skin or blood serum. Moreover, the sensitivity of detection of bilirubin was tuneable with the amount of Cu2+ added, thereby facilitating the detection of the desired concentration range of bilirubin.

| S-EPMC5157017 | biostudies-literature

Dynamic behaviour of platinum and copper dopants in gold nanoclusters supported on ceria catalysts.

Project description:Understanding the behaviour of active catalyst sites at the atomic level is crucial for optimizing catalytic performance. Here, the evolution of Pt and Cu dopants in Au25 clusters on CeO2 supports is investigated in the water-gas shift (WGS) reaction, using operando XAFS and DRIFTS. Different behaviour is observed for the Cu and Pt dopants during the pretreatment and reaction. The Cu migrates and builds clusters on the support, whereas the Pt creates single-atom active sites on the surface of the cluster, leading to better performance. Doping with both metals induces strong interactions and pretreatment and reaction conditions lead to the growth of the Au clusters, thereby affecting their catalytic behaviour. This highlights importance of understanding the behaviour of atoms at different stages of catalyst evolution. These insights into the atomic dynamics at the different stages are crucial for the precise optimisation of catalysts, which ultimately enables improved catalytic performance.

| S-EPMC10728199 | biostudies-literature

Functionalized Copper Nanoparticles with Gold Nanoclusters: Part I. Highly Selective Electrosynthesis of Hydrogen Peroxide

Project description: Not available

| S-EPMC10552511 | biostudies-literature

Dynamic surface reconstruction of individual gold nanoclusters by using a co-reactant enables color-tunable electrochemiluminescence.

Project description:Here we report for the first time the phenomenon of continuously color-tunable electrochemiluminescence (ECL) from individual gold nanoclusters (Au NCs) confined in a porous hydrogel matrix by adjusting the concentration of the co-reactant. Specifically, the hydrogel-confined Au NCs exhibit strong dual-color ECL in an aqueous solution with triethylamine (TEA) as a co-reactant, with a record-breaking quantum yield of 95%. Unlike previously reported Au NCs, the ECL origin of the hydrogel-confined Au NCs is related to both the Au(0) kernel and the Au(i)-S surface. Surprisingly, the surface-related ECL of Au NCs exhibits a wide color-tunable range of 625-829 nm, but the core-related ECL remains constant at 489 nm. Theoretical and experimental studies demonstrate that the color-tunable ECL is caused by the dynamic surface reconstruction of Au NCs and TEA radicals. This work opens up new avenues for dynamically manipulating the ECL spectra of core-shell emitters in biosensing and imaging research.

| S-EPMC10901519 | biostudies-literature

Fluorescence Sensing Approach for High Specific Detection of 2,4,6-Trinitrophenol Using Bright Cyan Blue Color-Emittive Poly(vinylpyrrolidone)-Supported Copper Nanoclusters as a Fluorophore.

Project description:In this paper, we illustrate an efficient, convenient, and simplistic fluorescence technique for the specific identification for nitro explosive 2,4,6-trinitrophenol (TNP) in 100% water medium by bright cyan blue color-emitting poly(vinylpyrrolidone)-supported copper nanoclusters (PVP-CuNCs) as a fluorescence probe. PVP-CuNCs exhibited linear fluorescence quenching response toward the increasing concentration of TNP analyte. Surprisingly, TNP only reduces the emission signal of PVP-CuNCs, whereas various nitro explosives cause very slight reducing emission intensity, validating the good specificity of the PVP-CuNC probe toward TNP. The highest Stern-Volmer quenching constant (K sv) value of 1.03 × 107 dm3 mol-1 and the extremely lowest limit of detection of 81.44 × 10-12 mol dm-3 were achieved solely for TNP in 100% water medium which is astonishing and exclusive for this nanoprobe. The sensing pathway for the high sensitivity of PVP-CuNCs assay to quantify the TNP is expected to combine with the inner filter effect process and static quenching. The static quenching mechanism between TNP and PVP-CuNCs is further verified by fluorescence decay measurements. Furthermore, the developed fluorescence sensing platform is applied for the quantification of a trace amount of TNP in real samples named dam water, sea water, and match stick.

| S-EPMC6644161 | biostudies-literature

Trace detection of tetrabromobisphenol A by SERS with DMAP-modified magnetic gold nanoclusters.

Project description:Magnetic gold nanoclusters (MGNCs) functionalized with 4-dimethylaminopyridine (DMAP) enables the trace detection of tetrabromobisphenol A (TBBPA), an environmental pollutant, using surface-enhanced Raman scattering (SERS) spectroscopy. The synthesis, cleansing, and functionalization of MGNCs are conducted in aqueous solutions; SERS samples are prepared by magnetic precipitation in the presence of trace analyte. The limit of detection (LOD) for TBBPA is greatly increased by the use of DMAP as a reporter molecule: DMAP-modified MGNCs can detect TBBPA at 10 pM in water, whereas the LOD for TBBPA by unfunctionalized Au is 1 nM. The reproducibility of picomolar TBBPA detection with DMAP-modified MGNCs is confirmed by two-dimensional correlation analysis. The high SERS sensitivity for TBBPA can be attributed to its capacity to modulate the Raman spectrum of adsorbed DMAP. This indirect mode of detection can also be applied toward the detection of other hydrophobic analytes, each identifiable by its characteristic SERS identity.

| S-EPMC4785030 | biostudies-literature

A Fluorescent Detection for Paraquat Based on β-CDs-Enhanced Fluorescent Gold Nanoclusters.

Project description:In this report, a fluorescent sensing method for paraquat based on gold nanoclusters (AuNCs) is proposed. It was found that paraquat could quench both glutathione-capped AuNCs (GSH-AuNCs) and β-cyclodextrin-modified GSH-AuNCs (GSH/β-CDs-AuNCs). The modification of β-CDs on the surface of GSH-AuNCs obviously enhanced the fluorescence intensity of GSH-AuNCs and improved the sensitivity of paraquat sensing more than 4-fold. This sensibilization was ascribed to the obvious fluorescence intensity enhancement of GSH-AuNCs by β-CDs and the "host-guest" interaction between paraquat and β-CDs. The fluorescence quenching was mainly due to the photoinduced energy transfer (PET) between GSH/β-CDs-AuNCs and paraquat. With the optimized β-CDs modification of the GSH-AuNC surfaces and under buffer conditions, the fluorescent detection for paraquat demonstrated a linear response in the range of 5.0-350 ng/mL with a detection limit of 1.2 ng/mL. The fluorescent method also showed high selectivity toward common pesticides. The interference from metal ions could be easily masked by ethylene diamine tetraacetic acid (EDTA). This method was applied to the measurement of paraquat-spiked water samples and good recoveries (93.6-103.8%) were obtained. The above results indicate that host molecule modification of fluorescent metal NC surfaces has high potential in the development of robust fluorescent sensors.

| S-EPMC8225061 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data