Dataset Information

Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F_2? in wastewater associated with tobacco use.

ABSTRACT: Wastewater analysis has been demonstrated to be a complementary approach for assessing the overall patterns of drug use by a population while the full potential of wastewater-based epidemiology has yet to be explored. F₂-isoprostanes are a prototype wastewater biomarker to study the cumulative oxidative stress at a community level. In this work, 8-iso-prostaglandin F_2? (8-iso-PGF_2?) was analysed in raw 24?h-composite wastewater samples collected from 4 Norwegian and 7 other European cities in 2014 and 2015. Using the same samples, biomarkers of alcohol (ethyl sulfate) and tobacco (trans-3'-hydroxycotinine) use were also analysed to investigate any possible correlation between 8-iso-PGF_2? and the consumption of the two drugs. The estimated per capita daily loads of 8-iso-PGF_2? in the 11 cities ranged between 2.5 and 9.9?mg/day/1000 inhabitants with a population-weighted mean of 4.8?mg/day/1000 inhabitants. There were no temporal trends observed in the levels of 8-iso-PGF_2?, however, spatial differences were found at the inter-city level correlating to the degree of urbanisation. The 8-iso-PGF_2? mass load was found to be strongly associated with that of trans-3'-hydroxycotinine while it showed no correlation with ethyl sulfate. The present study shows the potential for 8-iso-PGF_2? as a wastewater biomarker for the assessment of community public health.

SUBMITTER: Ryu Y

PROVIDER: S-EPMC5157025 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F2α in wastewater associated with tobacco use.

Ryu Yeonsuk Y Gracia-Lor Emma E Bade Richard R Baz-Lomba J A JA Bramness Jørgen G JG Castiglioni Sara S Castrignanò Erika E Causanilles Ana A Covaci Adrian A de Voogt Pim P Hernandez Felix F Kasprzyk-Hordern Barbara B Kinyua Juliet J McCall Ann-Kathrin AK Ort Christoph C Plósz Benedek G BG Ramin Pedram P Rousis Nikolaos I NI Reid Malcolm J MJ Thomas Kevin V KV

Scientific reports 20161215

Wastewater analysis has been demonstrated to be a complementary approach for assessing the overall patterns of drug use by a population while the full potential of wastewater-based epidemiology has yet to be explored. F2-isoprostanes are a prototype wastewater biomarker to study the cumulative oxidative stress at a community level. In this work, 8-iso-prostaglandin F2α (8-iso-PGF2α) was analysed in raw 24 h-composite wastewater samples collected from 4 Norwegian ...[more]

PMID: 27976726

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Project description:The widespread detection of elevated oxidative stress levels in many medical conditions has led to numerous efforts to design interventions to reduce its effects. Efforts have been wide-ranging, from dietary changes to administration of antioxidants, supplements, e.g., omega-3-fatty acids, and many medications. However, there is still no systemic assessment of the efficacy of treatments for oxidative stress reduction across a variety of medical conditions. The goal of this meta-analysis is, by combining multiple studies, to quantitate the change in the levels of the popular oxidative stress biomarker 8-iso-prostaglandin F2? (8-iso-PGF2?) after a variety of treatment strategies in human populations. Nearly 350 unique publications with 180 distinct strategies were included in the analysis. For each strategy, the difference between pre- or placebo and post-treatment levels calculated using Hedges' g value of effect. In general, administration of antibiotics, antihyperlipidemic agents, or changes in lifestyle (g = -?0.63, -?0.54, and 0.56) had the largest effect. Administration of supplements, antioxidants, or changes in diet (g = -?0.09, -?0.28, -?0.12) had small quantitative effects. To fully interpret the effectiveness of these treatments, comparisons to the increase in g value for each medical condition is required. For example, antioxidants in populations with coronary artery disease (CAD) reduce the 8-iso-PGF2? levels by g =?-?0.34?±?0.1, which is quantitatively considered a small effect. However, CAD populations, in comparison to healthy populations, have an increase in 8-iso-PGF2? levels by g =?0.38?±?0.04; therefore, the overall reduction of 8-iso-PGF2? levels is ??90% by this treatment in this specific medical condition. In conclusion, 8-iso-PGF2? levels can be reduced not only by antioxidants but by many other strategies. Not all strategies are equally effective at reducing 8-iso-PGF2? levels. In addition, the effectiveness of any strategy can be assessed only in relation to the medical condition investigated.

Project description:Media utilization has been identified as an important determinant of tobacco use. We examined the association between self-reported tobacco use and frequency of mass media utilization by women and men in nine low-to middle-income sub-Saharan African countries.Data for the study came from Demographic and Health Surveys conducted in Burkina Faso, Ethiopia, Liberia, Lesotho, Malawi, Swaziland, Uganda, Zambia and Zimbabwe over the period 2006-2011. Each survey population was a cross-sectional sample of women aged 15-49 years and men aged 15-59 years, with information on tobacco use and media access being obtained by face-to-face interviews. An index of media utilization was constructed based on responses to questions on the frequency of reading newspapers, frequency of watching television and frequency of listening to the radio. Demographic and socioeconomic variables were considered as potentially confounding covariates. Logistic regression models with country and cluster specific random effects were estimated for the pooled data.The risk of cigarette smoking increased with greater utilization to mass media. The use of smokeless tobacco and tobacco use in general declined with greater utilization to mass media. The risk of tobacco use was 5% lower in women with high media utilization compared to those with low media utilization [Adjusted Odds Ratio (AOR) = 0.95, 95% confidence interval (CI):0.82-1.00]. Men with a high media utilization were 21% less likely to use tobacco compared to those with low media utilization [AOR = 0.79, 95%CI = 0.73-0.85]. In the male sample, tobacco use also declined with the increased frequency of reading newspapers (or magazines), listening to radio and watching television.Mass media campaigns, conducted in the context of comprehensive tobacco control programmes, can reduce the prevalence of tobacco smoking in sub-Saharan Africa. The reach, intensity, duration and type of messages are important aspects of the campaigns but need to also address all forms of tobacco use.

Project description:BACKGROUND:Lower socioeconomic status (SES) and psychosocial stress during pregnancy have been associated with adverse birth outcomes. While hypothalamic-pituitary-axis activation is thought to be the primary driver, oxidative stress may also be involved mechanistically. We used data from the Puerto Rico Testsite for Exploring Contamination Threats (PROTECT) cohort (N=476) to examine associations between self-reported psychosocial stress measures, SES indicators, and urinary oxidative stress biomarker concentrations, hypothesizing that women with lower SES and increased psychosocial stress would have elevated oxidative stress biomarkers. METHODS:Maternal age, education, marital status, insurance status, alcohol use and smoking status were obtained via self-reported questionnaires and were used as indicators of SES. Perceived stress, depression, negative life experiences, neighborhood perceptions, and social support were self-reported in questionnaires administered during pregnancy. Responses were grouped into tertiles for analysis, where the highest tertile corresponded to highest level of psychosocial stress. Urinary concentrations of 8-iso-prostaglandin F2? (8-iso-PGF2?) and its primary metabolite were measured at three study visits (median 18, 24, 28 weeks gestation) and averaged to reflect oxidative stress across pregnancy. Linear models were used to examine associations between SES indicators, tertiles of psychosocial stress and oxidative stress biomarkers. RESULTS:Average levels of 8-iso-PGF2? and the 8-iso-PGF2? metabolite were higher among pregnant women who were younger, who had public compared to private insurance, and who were unemployed compared to employed. However, no associations were observed between psychosocial stress measures and biomarker concentrations in adjusted analyses. CONCLUSIONS:Psychosocial stress during pregnancy, as indicated by self-reported questionnaire measures, was not associated with biomarkers of oxidative stress in the PROTECT study. However, results suggest that these biomarkers are elevated among women of lower SES, which is typically associated with stress. Notably, compared to other populations, self-reported psychosocial stress measures were lower in PROTECT compared to other populations.

Dataset Information

Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F_2? in wastewater associated with tobacco use.

Publications

Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F<sub>2α</sub> in wastewater associated with tobacco use.

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OmicsDI is part of the ELIXIR infrastructure

Dataset Information

Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F2? in wastewater associated with tobacco use.

Publications

Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F<sub>2α</sub> in wastewater associated with tobacco use.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F_2? in wastewater associated with tobacco use.